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4 edition of Regulation of the D1 dopamine receptor in rat brain and SK-N-Mc human neuroblastoma cells found in the catalog.

Regulation of the D1 dopamine receptor in rat brain and SK-N-Mc human neuroblastoma cells

Tinku S. Mukherjee

Regulation of the D1 dopamine receptor in rat brain and SK-N-Mc human neuroblastoma cells

by Tinku S. Mukherjee

  • 15 Want to read
  • 26 Currently reading

Published by National Library of Canada = Bibliothèque nationale du Canada in Ottawa .
Written in English


Edition Notes

SeriesCanadian theses = Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches.
ID Numbers
Open LibraryOL16498819M
ISBN 100612021807
OCLC/WorldCa46496874

For example, the expression of SULT1A3 was found to be induced by its prototype substrate, dopamine, via ERK pathway in SK-N-MC and SH-SY5Y human neuroblastoma cells. 65) Ethanol has been shown to induce ethanol-sulfating SULTs, 66,67) SULT1A1 and SULT1E1, in cultured HepG2 human hepatoma cells. 68) Interestingly, 17β-estradiol, a substrate Cited by:   Excessive D 1 Dopamine Receptor Activation in the Dorsal Striatum Promotes Autistic-Like Behaviors. PubMed. Lee, Yunjin; Kim, Hannah; Kim, Ji-Eun; Park, Jin-Young.

  Neuroprotective effects of maysin, which is a flavone glycoside that was isolated from the corn silk (CS, Zea mays L.) of a Korean hybrid corn Kwangpyeongok, against oxidative stress (H 2 O 2)-induced apoptotic cell death of human neuroblastoma SK-N-MC cells were investigated. Maysin cytotoxicity was determined by measuring cell viability using. G Protein-Coupled Receptors as Drug Targets Edited by Roland Seifert, Thomas Wieland Methods and Principles in Medicinal Chemistry Edited by R. R. Mannhold, H. Kubinyi, G. Folkers Editorial Board H.-D. Ho¨ltje, H. Timmerman, J. Vacca, H. van de Waterbeemd, T. Wieland.

expression in the neostriatum or nucleus accumbens, strongly suggesting that G o l f mediates D1 receptor signaling to adenylate cyclase in these basal ganglia nuclei (5,8). Less is known about the subunits that combine with G s or G o l f to mediate D1-like receptor activation of adenylate cyclase. In human embryonic kidney (HEK) cells, depletion of endogenous 7 subunit reduces D1. CGRP receptors are widely distributed in the nervous and cardiovascular systems. To date, two isotypes have been described. On pharmacological evidence, CGRP1 receptors, such as those identified in human SK-N-MC neuroblastoma cells, recognize intact CGRP and CGRP(8–37) with similar potency, unlike a linear analog lacking the disulfide bridge.


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Regulation of the D1 dopamine receptor in rat brain and SK-N-Mc human neuroblastoma cells by Tinku S. Mukherjee Download PDF EPUB FB2

Studies in SK-N-MC human neuroblastoma cells, which express endogenous D1 receptors, have shown a bimodal regulation of D1 receptor expression by dopamine and D1 receptor agonist, SKF, wherein an initial upregulation is followed by a downregulation of endogenous D1 receptor mRNA (Sidhu, Olde, Humblot, Kimura, & Gardner, ).Author: Eldo Kuzhikandathil.

PDF | Dopamine receptors, in particular the dopamine D1 receptor subtype, mediate the physiological and behavioral responses elicited by cocaine.

| Find, read and cite all the research you need. The dopamine receptor agonist dihydrexidine, which raised cAMP levels 22%, promoted regulatory changes in EphrinA1, EphrinA5, EphB1, DCC, and Semaphorin3C, whereas (+/-).

Abstract. Dopamine receptors belong to the large family of heptahelical transmembrane spanning G protein-coupled receptors (GPCRs). Five mammalian dopamine receptor subtypes have been identified and are classified into two major groups, the D1-like (D 1 and D 5) and D2-like (D 2, D 3, and D 4) splice variants of the D 2 receptor exist, D 2-Long (D 2L) and D 2-Short (D Cited by: Abstract.

Regulation of receptor responsiveness by neurotransmitters and hormones is a well-recognized phenomenon that has been demonstrated for most receptor systems (1).Such regulation can involve desensitization, the tendency of receptor responsiveness to wane over time despite the presence of a stimulus of constant intensity; or amplification, in which the receptor system becomes Cited by: Dopamine, which is synthesized in the kidney, independent of renal nerves, plays an important role in the regulation of fluid and electrolyte balance and systemic blood pressure.

Lack of any of the five dopamine receptor subtypes (D1R, D2R, D3R, D4R, and D5R) results in hypertension. D1R, D2R, and D5R have been reported to be important in the maintenance of a normal redox by: Human SK-N-SH neuroblastoma cells: Inhibition of cell proliferation Apoptosis Necrosis: Luo and Miller, b McAlhany et al., Human IMR32 neuroblastoma cells: Inhibition of cell proliferation: Luo and Miller, b: Human SK-N-MC neuroblastoma cells: Apoptosis: Jang et al., Murine N2a neuroblastoma cells: Apoptosis: Kang et al., Cited by: 3.

Dopamine systems and their receptors. There are three major brain dopamine pathways: the nigrostriatal (from cells in the A9 region); the mesolimbic and mesocortical systems (from cells in the A10 or ventral tegmentum); and the tuberoinfundibular (hypothalamic) system [].The first evidence for a biochemical mechanism of dopamine neurotransmission was the observation that dopamine could Cited by: The Expression of GSK3β in the Developing Brain.

GSK3β is widely expressed in all tissues and is particularly abundant in the central nervous system [].In the developing brain, GSK3β is predominantly expressed in neurons and barely detectable in astrocytes [50, 51].Leroy and Brion [] show the expression of GSK3β in the developing rat brain is highest from 18 days of embryonic life up to 10 Cited by: In one study, the D2 agonist quinpirole ( mg/kg) potentiated QC ( mg/kg) antinociceptive activity, but dopamine D1 receptor agonist, SKF (10 and 15 mg/kg), was unsuccessful in modifying the QC-mediated antinociceptive effect.

QC ( mg/kg) prevented reserpine-intoxicated (2 mg/kg, 4 h) hyperalgesia, which was inverted by by: 1. Pifl C, Khorchide M, Kattinger A, Reither H, Hardy J, Hornykiewicz O () alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter Neurosci Lett, o.

;S.K. Gupta & R.K. Mishra, “Desensitization of D1 Dopamine Receptors Down-Regulates the Gs&agr Subunit of G Protein in SK-N-MC Neuroblastoma Cells,” J. Mol. Neurosci. 4: ().

;4: (). S.K. Gupta & R.K. Mishra, “Up-Regulation of D1 Dopamine Receptors in SK-N-MC Cells After Chronic Treatment with SCH ,” Neurosci. Structure of a parathyroid hormone/parathyroid hormone-related peptide receptor of the human cerebellum and functional expression in human neuroblastoma SK-N-MC cells.

Mol. Brain. The proteasome inhibition model is particular by inducing nigral DA neurodegeneration via a distinct, but highly relevant mechanism of action. Notably, the model emulates the accumulation and aggregation of endogenous α-synuclein, a feature which has been difficult to Cited by:   Methods for treatment of disease-induced peripheral neuropathy and related conditions “Desensitization of D1 Dopamine Receptors Down-Regulates the Gs&agr Subunit of G Protein in SK-N-MC Neuroblastoma Cells,” J.

Mol. Neurosci. 4: (). “Up-Regulation of D1 Dopamine Receptors in SK-N-MC Cells After Chronic Treatment with. In human neuroblastoma SH-SY5Y cells, isradipine antagonized many effects of rotenone including production of reactive oxygen species, G1/G0 cell cycle arrest, and activation of p53/p21 signaling proteins as well as the decreased expression of the signaling proteins for cell proliferation and survival, Cyclin-dependent kinase 2, cyclin D1, and by: 3.

GSK3β in Ethanol Neurotoxicity GSK3β in Ethanol Neurotoxicity Luo, Jia Alcohol consumption during pregnancy is a significant public health problem and may result in a wide range of adverse outcomes for the child.

The developing central nervous system (CNS) is particularly susceptible to ethanol toxicity. Introduction: Annexin A1 (ANXA1) is mainly expressed in astrocytes and ependymal cells of normal human brains.

Regarding acute ischemic brain, increased expression of ANXA1 in microglia and vascular endothelium has been shown with rodent models; however, astrocytic expression of ANXA1 in infarcted brain tissues has been little focused on. This banner text can have markup.

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In human embryonic kidney (HEK) and neuroblastoma SK-N-MC cells rotenone ( nM, 24 hr) was found to inhibit 26S UPS activity (by 25%, at 10 nM) (Chou et al., ).

Rotenone was found to interfere with MT assembly at concentrations as low as 10 nM, providing evidence that there could be additional mechanisms implicated in the rotenone.Work With Your Doctor is an easy book to read; in spite of this, every recommendation provided is also supported by solid research that the reader can share with his or her health care provider.

This makes this wonderful book a treasure trove of ‘clinical pearls’ that I. MxA was associated with the risk of AD in clinical AD group (pSK-N-MC, HeLa and OVCAR